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Author(s): Etah E. Nkanu, Kayode Dasofunjo, Kebe Obeten.

Volume/Issue: Volume 4 , Issue 1 (2021)

Abstract:

Acetaminophen is an organic compound that is commonly used as an antipyretic and analgesic drug. Acetamenophen may cause liver injury and cardiac dysfunction because of complex cardiohepatic interactions.The aim of this study is to assess the possible effect of acetamenophen intake and taxifolin supplementation on some cardiovascular risk factors like tumour necrosis factor-alpha(TNF-α), interleukin-6(IL-6), troponin, and lipid profile in Wistar rats. Four groups of Wistar rats containing five rats each were used. Group 1(control) received normal feed and water. Group 2 received 500mg/kg body weight of acetaminophen(ACTMP), group 3 received 500mg/kg of ACTMP and 1mg/kg body weight of taxifolin (TXF) orally. Group 4 received 1mg/kg of TXF. Feeding and treatment lasted for 5 weeks. Blood samples were collected through cardiac puncture into blood sample bottles and centrifuged to obtain serum. Interleukin-6, troponin and TNF-α concentrations were determined using ELISA kits and following manufacturers procedures. Results showed that tumor necrosis factor-alpha (TNF-α), IL-6 and troponin in ACTMP were significantly(p<0.05) higher than control while lactate dehydrogenase(LDH) was reduced in ACTMP. Lipid profile was significantly (p<0.05) reduced in ACTMP. Treatment with taxifolin significantly (p<0.01) lowered IL-6, troponin, and LDH. We conclude that Acetamenophen intake may alter serum level of IL-6, TNF-α and troponin which are risk factors of cardiotoxicity while taxifolin has little or no effect on TNF-α and troponin but may suppress IL-6 activity.

Keywords:

Acetaminophen, Taxifolin, Interleukins, Troponin, Tumor Necrosis Factor, Lipids

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