Anti-Diarrhea Efficacy Of Annona muricata L. On Animal Model

Abstract:

Diarrhea is known for its severe health threat associated with individuals. The treatment is associated with the possible uses of Annona muricata ethnomedicinal report. This study evaluates the efficacy of A. muricata ethanol and hexane leaves extracts on diarrhea. The pulverized sample was macerated using ethanol and hexane solvent. The acute toxicity report was experimented on mice model. Effects of A. muricata on gastro-intestinal tract disorders were assessed in castor oil- induced diarrhea and charcoal meal model in experimental animals at graded doses of 30-120 mg/kg of ethanol and hexane leaves extracts, when compared with standard drug and untreated control. The animals were able to withstand ethanol and hexane extract at highest toxicity dose of 5 g/kg with no visible toxicity sign. Significant peristalsis inhibitions were observed in the treated groups at 30, 60 and 120 mg/kg of A. muricata extracts which triggered a definite reduction in the distance travelled by charcoal when compared with the distance of the small intestinal with dose dependent. Also, it showed reduction in the weight and number of diarrhea stool, with prolong onset of action in castor oil induced diarrhea. The results acquire validate the ethnomedicinal uses of A. muricata.