Abstract:

Brain death is the cause of a major inflammatory systemic response syndrome (SIRS) affecting all the organs and partly responsible for their dysfunction. One of these consequences is kidney failure (AKI: Acute Kidney Injury). Between September 2008 and September 2013, renal function was analyzed in patients admitted for severe head injury who progressed to brain death. Impairment of renal function has been demonstrated in these subjects upon admission, suggesting a direct interaction between the brain and the kidney. An early deterioration of renal function in the subject in a brain death state is often highlighted in our study, its occurrence results from the addition of hemodynamic, neurohormonal and inflammatory factors.