Invitro Analysis of Time-Kill Curves of Some Antimicrobial Agents Against Salmonella Typhi

Aliyu A.S.; Ahmed I.; Abdulmalik I.; Shamsiyya M.S.; Usman Y.S.; Sadisu F.U.; Haruna M.

doi:10.52589/AJBMR-ITLIZNET

Invitro Analysis of Time-Kill Curves of Some Antimicrobial Agents Against Salmonella Typhi

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African Journal of Biology and Medical Research

Vol. 4Issue 32021pp. 108–118Published 31 August 2021

DOI 10.52589/AJBMR-ITLIZNET

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Abstract:

Due to the high prevalence of typhoid fever and Salmonella infections' periodic nature despite the various antimicrobial agents used to treat this infection, the need to open up new strategies for antimicrobial susceptibility rather than the MIC alone arises. This study determines the time-kill curves using four different antimicrobial agents; Gentamicin, Ceftriaxone, Cloxacillin, and Ofloxacin at different concentrations of 1x, 2x, and 4x of their MICs. The finding of this study reveals that at 1x MIC all the antimicrobial used except for gentamicin shows non-bactericidal activity against the isolates after eight hours of exposure. This study suggests that analyzing the time-kill curves in typhoid fever treatment will help determine the appropriate dose to treat the infection. Key Words; Antimicrobial, Time-kill Curves, Salmonella Typhi,

Keywords:Antimicrobial Time-kill Curves Salmonella Typhi.

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