Effects of Fetal Microchimerism on Female Breast Cancer: State of the Art and Evolutionary Point of View

Abstract:

Introduction: Fetal microchimerism is a frequent phenomenon occurring in all human pregnancies, which allows the transfer of fetal cells of various phenotypes to the mother. Recent data suggest an association between pregnancy, microchimerism, and cancer. A pregnancy history has been identified as a consistent protective factor against breast cancer. Thus, it is conceivable that undefined characteristics of previous pregnancies could explain why some women with positive parity have a reduced risk of breast cancer while others do not. In this context, we undertook this study to evaluate the relationship between fetal microchimerism and female breast cancers through a literature review. Materials and Methods: To meet this objective, namely, to evaluate the relationship between fetal microchimerism and female breast cancer, a literature review was performed using mainly a bibliographic data search engine (Pubmed). Results and Discussion: This study found microchimerism more in healthy women than women with breast cancer, with a statistically significant difference. These results suggest that microchimeric cells may reduce the risk of breast cancer in women. This protective effect may be explained by the differentiation and tissue regeneration properties associated with the immunoregulatory properties of fetal microchimeric stem cells. However, the correlation is not linear. Conclusion: In this study, our results indicate that microchemical cells may help reduce the risk of breast cancer in women. Good knowledge of the mechanisms of these microchemical stem cells could potentially serve as an innovative therapeutic approach for breast cancer patients.