Effect of Seven Antiretroviral Combinations on Biochemical Parameters in HIV Positive Patients at the National Blood Transfusion Center of Abidjan

Tovi Wahon Marie-Odile; Abo Yao; Minga Kla Albert; Kouakou Koffi

doi:10.52589/AJBMR-VLJJRYIM

Effect of Seven Antiretroviral Combinations on Biochemical Parameters in HIV Positive Patients at the National Blood Transfusion Center of Abidjan | AB Journals

Effect of Seven Antiretroviral Combinations on Biochemical Parameters in HIV Positive Patients at the National Blood Transfusion Center of Abidjan

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African Journal of Biology and Medical Research

Vol. 6Issue 12023pp. 24–34Published 23 January 2023

DOI 10.52589/AJBMR-VLJJRYIM

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Abstract:

In order to contribute to the knowledge of the effects of antiretroviral drugs, a descriptive study was conducted on HIV patients who started antiretroviral therapy (ART). The 321 patients who were the subject of this study were selected from the cohort of HIV-infected patients followed at the Centre Médical de Suivi des Donateurs de Sang (CMSDS) in Abidjan (RCI), in the period from 2005 to 2012. These patients received regularly, according to their condition, seven (7) ARV therapeutic combinations which are AZT-3TC-EFV, AZT-3TC-NVP, AZT-3TC-NFV, AZT-3TC-LOP/RIT, DT4-3TC-EFV, DT4-3TC-NVP, and FTC-TDF-EFV. Biological check-ups performed every six (6) months allowed to follow these patients during 36 months of treatment and biological parameters were measured. The results on transaminases (GOT, GPT) and creatinine do not show toxicity of these different treatments on the hepatic and renal functions.

Keywords:arv hiv liver toxicity renal toxicity.

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