Assessment of the Migration/Invasion Traits of Acquired Resistant BT 549 Gem100nM Breast Cancer Cell Lines.

Tawari Erebi Patricia

doi:10.52589/AJBMR-MW43GIZO

Assessment of the Migration/Invasion Traits of Acquired Resistant BT 549 Gem100nM Breast Cancer Cell Lines.

African Journal of Biology and Medical Research

Vol. 7Issue 42026pp. 90–96Published 11 May 2026

DOI 10.52589/AJBMR-MW43GIZO

Research Article

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Abstract:

One of a cell's behavioral characteristics is migration. Cell migration is a major contributor to cancer-related mortality and plays a significant role in the spread of metastatic tumors. The purpose of this study was to evaluate the invasive characteristics and migration traits of acquired gemcitabine-resistant BT 549 Gem100nM breast cancer cell lines. According to data from the results obtained, the resistant cell lines Clones 1 and 4 exhibited higher migratory and invasive activities than the wild-type cell line BT549. This suggests that acquired resistance may cause cancer cells to become more lethal by increasing their migratory and invasive characteristics.

Keywords:Migration Invasion Acquired Resistance BT 549 breast cancer cells.

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