Updated profile of Clinical Manifestations of Onchocerciasis After Repeated Ivermectin Treatment in Middle Imo River Basin, Nigeria.

Amaechi Austin; Iwunze John; Uzowuru Daniel; Ebeh-Njoku Augusta; Chimara Osinachi; Alisi Goodlick; Nwokeji Modebe; Tony-Nze Chizoba

doi:10.52589/AJBMR-IFZAK9VQ

Updated profile of Clinical Manifestations of Onchocerciasis After Repeated Ivermectin Treatment in Middle Imo River Basin, Nigeria.

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African Journal of Biology and Medical Research

Vol. 7Issue 42024pp. 23–30Published 18 October 2024

DOI 10.52589/AJBMR-IFZAK9VQ

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Abstract:

We conducted a cross-sectional survey on the impact of ivermectin after repeated treatment in five communities in Imo State, Nigeria. Rapid epidemiological mapping of onchocerciasis (REMO) carried out in 450 subjects in 1994 prior to the launching of mass drug administration were compared with re-examinations of 540 subjects in 2023. We found palpable nodule reduction from 47.2% to 12.2% and popular dermatitis decrease from 42.9% to 5.9%. Reductions in other clinical features were observed. Overall, a significantly higher proportions of males were infected than females (P<0.05). The implications of these results were discussed in line with the reported benefits of ivermectin therapy.

Keywords:clinical manifestations ivermectin prevalence palpation.

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