Analysis of Transmission Dynamics and Control of Strongyloides Stercoralis using Mathematical Modeling in Pankshin Local Government Area of Plateau State, Nigeria.

Abstract:

Strongyloides stercoralis’ infection is common among children living in rural areas in developing countries especially in Sub-Saharan Africa with serious public health significance. This study presents a mathematical modeling and analysis of transmission dynamics and control of Strongyloides stercoralis in Pankshin Local Government Area of Plateau State, Nigeria. A mathematical model based on the Susceptible-Exposed-Infected-Treated-Public Health Education-Filariform Larvae (SEITPF) compartments for Strongyloides stercoralis was formulated. A qualitative analysis was performed and disease equilibrium points together with their stabilities. The basic reproduction number, R0, is computed and used as a threshold value using the next generation matrix method. It is established that the unique endemic equilibrium point is locally asymptotically stable provided R0 >1. Additionally, to ascertain the impact of various parameter values on the growth of Strongyloides stercoralis, a sensitivity analysis of R0 was conducted. Ultimately, a numerical analysis of these parameters' effects on the infected humans revealed that treatment, public health education, and good personal hygiene should all be used in tandem to effectively eradicate Strongyloides stercoralis and other NTDs infections in the study area.