Abstract:

Neurotransmitters are signaling molecules that travels across the synaptic space to interact with receptors. In this study the relationship between the serotonin and dopamine was highlighted in Schizophrenia. Serotonin and Dopamine have individual roles in the progression of the disease, but interesting results had focused on interactive role. Earlier researches had highlighted that the serotonin system inhibits the dopaminergic function at the level of origin of the dopamine system in the mid-brain as well as at the terminal dopaminergic field in the fore-brain. To conclude the therapeutic success of clozapine and risperidone had revealed that two systems act as an avenue for superior therapeutic actions in schizophrenia.