Gastro-Protective Role of Solanum Aethiopicum Ethanol Extract in Potassium Bromate-Induced Toxicity in Rats.

Abstract:

This study was aimed at investigating the gastro-protective role of Solanium aethiopicum ethanolic extract on lipid profile in potassium bromate-induced toxicity in wistar rats. The treatment lasted for 28 days. Thirty (35) rats weighing 140g-150g were used in this study were separated into five groups of 7 rats. Groups 3 ,4 and 5 were pre-treated with 50mg/kg of potassium bromate for 2 weeks. Group 1 (control) were given normal feed and 0.2ml of normal saline. Group 2 were administered 50mg/kg of potassium bromate for 2weeks. Group 3 and 4 received 300mg/kg and 600mg/kg of Solanium aethiopicum extract respectively. Group 5 was administered with 100mg/kg of Vitamin C. After 28 days of administration, the animals were subjected to fasting for 24 hours and were anaesthetized, sacrificed and blood was collected by cardiac puncture, spinned and the serum used to carry out tests for lipid profile. In another set of fifty (50) male Wistar rats (150–190 g) were randomly divided into five groups (n=10) and were sacrificed to access pepsin activity, and mucus secretion. Juice collected from the stomachs were also subjected to pH, pepsin activity and total acidity tests. Low doses (significantly P<0.05) decreased lipid profile compared to vitamin C. Statistical analysis were conducted using one way analysis of variance (ANOVA) together with post hoc test at P<0.05. The low dose of extract significantly(P<0.05) increased mucus secretion, pH level, reduced acidity, pepsin output in the stomach and reduced intestinal motility.