Prevalence and Antibiotic Resistance Profile of Extended-Spectrum Beta-Lactamase-Producing Uropathogenic Enterobacteriaceae Isolated at the Bacteriology-Virology Laboratory of Chnu De Fann, Dakar.

Abstract:

Introduction: Urinary tract infections caused by Enterobacteriaceae producing extended- spectrum β-lactamases represent a growing infectious risk, and in many cases may even lead to therapeutic impasses due to their multi-resistance to antibiotics. The aim of this study was to determine the antibiotic susceptibility profile of extended-spectrum betalactamase-secreting uropathogenic enterobacteriaceae isolated at the CHNU de Fann, Dakar . Material and Methods: This was a retrospective study lasting six months (from January 1 to June 30, 2018) concerning all uropathogenic E-BLSE strains isolated at the Bacteriology- Virology laboratory of the CHNU de Fann (Dakar). Results: This study revealed a high prevalence of E-BLSE isolation (41.8%), particularly in outpatients (65.67%). The most represented age group was between 60 and 80 years, with a percentage of 48.11%. E. coli was the most isolated germ (51.49%), followed by Klebsiella pneumoniae (26.87%). A study of the susceptibility profile of EBLSE to other antibiotic molecules revealed high levels of resistance, reaching 100% for sulfamethoxazole trimethoprim and fosfomycin, and 91.3 % for fluoroquinolones. For aminoglycosides, high co-resistance was observed with gentamicin (85.7%), while it was low with amikacin (3.84%). Our results also showed 100% sensitivity to imipenem. Conslusion: The emergence of extended-spectrum ß-lactamase-producing urinary tract infections is a major public health problem. Faced with this alarming and worrying situation, and in order to limit the emergence of healthcare-associated infections, it has become imperative to improve hospital hygiene. Key words: Urinary tract infections, enterobacteria, ESBL, CHNU de Fann.