Latent Demographic and Clinical Correlates of Drug Resistant Tuberculosis Among Treated Patients

Abstract:

Demographic and Clinical variables (data) collected from tuberculosis patients whose cases were drug resistant were analysed. The tuberculosis patients studied were those treated in the 11 Local Governments Areas and a treatment centre of Anambra State, Nigeria, for six years (2017 – 2022). Data from 197 Drug Resistant Tuberculosis (DR-TB) patients were analysed. The pair of data collected, being multivariate in nature, were analysed using the Canonical Correlation Analysis (CCA) and the Canonical loadings (structure coefficients) between the Demographic and Clinical Variables were extracted. Data obtained showed that mean age of the study participants was 40.2 ± 18.9 years (95% Confidence Interval). Males were 60.9%. Participants with HIV co-infection was 22.3%. The CCA showed that the first canonical variate was significant with 79% contribution, extracting 28.5% of the variance from demographic variables and 6.7% variance from the clinical variables. The variables that significantly contributed to the relationship include Age, Location and Body Mass Index (BMI). Human Immuno-Deficiency Virus (HIV) negative was protective in the relationship but not statistically significant.