Modelling the Impact of Relapse and Weaning Off Immunity on Hepatitis B Virus Transmission Dynamics.

Nwaokolo M. A.; Oguche A. J.; Umaru R.; Nwaokolo B.

doi:10.52589/IJPHP-RRT1W4KI

Modelling the Impact of Relapse and Weaning Off Immunity on Hepatitis B Virus Transmission Dynamics.

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International Journal of Public Health and Pharmacology

Vol. 4Issue 12024pp. 74–93Published 2 July 2024

DOI 10.52589/IJPHP-RRT1W4KI

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Abstract:

In this study, we present a numerical simulation of the impact of relapse in patients with chronic HBV infection and weaning off immunity on vaccinated individuals within the transmission dynamics of Hepatitis B. The sensitivity analysis result establishes that relapse rate and weaning off immunity increases the value of the effective reproduction number when it is increased. Similarly, the result of the numerical simulation reveals that the combine effect of relapse and weaning off immunity increases the number of infected persons and thus, increase the spread of the Hepatitis B Virus. Also, relapse delays the quick response to the treatment regimen which consequently slows down the potential of recovery from the infection, whereas, weaning off immunity reduces the number of vaccinated individuals .

Keywords:Hepatitis B Virus treatment relapse.

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