Effect of Jute Leaves on Indomethacin-Induced Ulcer.

Abstract:

Excessive stomach acid secretion can erode oesophageal tissue, causing swelling, bleeding, and occasionally a peptic ulcer disease. This study aimed to understand the dose-dependent effect of Corchorus olitorius to ameliorate the effects of gastric acid secretion. 44 rats were divided into 2 groups: pre- and post-treatment groups, which were further subdivided into 6 groups each. The pretreatment group had the normal control, negative control, standard group receiving 0.2ml/kg of oral sucralfate and 3 groups receiving Corchorus olitorius extract at doses of 0.9ml/kg, 1.8ml/kg and 3.6ml/kg, respectively. All animals in the pretreatments were orally administered the extract for 7 days. On the 8th day, all except the normal group were induced with a gastric ulcer using indomethacin. After 24hours, the rats were sedated using diethyl ether, their stomachs were all harvested, and then, blood samples were collected. It was observed that indomethacin caused severe gastric ulcers, which were reversed by Corchorus olitorius extract. Visible changes were observed in immunoglobulin levels, indicating the anti-inflammatory and mucosal protective properties of this treatment.