| 1 |
Author(s):
Hameeda Ibrahim Ahmed Mustafa, Bakheta Adil Jalal Mnallah, Zeinab Hamadalneel Ahmed Muhammed, Marwa Muhammad Saeed Mustafa, Hiba Ismael Musa Mohajer.
Page No : 1-12
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Screening of Urine Cytology for changes Due to Long Term Effects of Urinary Schistosomiasis in Managil City, Gezira State, Sudan.
Abstract
Schistosomiasis or bilharziasis is water-borne flatworms affects approximately 200 million people worldwide. This cross sectional laboratory based study to screen urine for cytological changes in urinary Schistosomiasis patients, in individual previously diagnose. From 89 patients (88 male and 1 female) represented the study group voided urine samples collected in sterile container, centrifuged and prepare as monolayer smear, fixed before air dying in 95% ethanol and stain by pap stain. The results was:
The majority of study group 36/89 (40%) were workers and 53/89 (60%) students. Most affected group age range (11-20) years. Microscopic examination demonstrate urine crystals 24/89 (27%) samples, while 65/89 (73%) of samples were negative.11/89 (12%) contains yeast cells and 78/89 (88%) were negative. 5/89 (6%) contains urine cast and 84/89 (94%) were negative. Positive cases as follow: 3/5 hyaline cast and 2/5 cellular cast. Most of the smears were hypocellular (3-5 cells/field). Cellularity according to the type of cells: normal urothelial cell present in (9) samples (10%) intermediated epithelial cells present in (8) samples (9%). Corpora amylacea present in (5) samples (6%). Condyloma acuinatum present in (1) sample (1%). Cells show Koliocytosis similar to that of cervical infection. One patient has hematouria (1%) with elements indicate active cystitis. In addition to this sample another (16) samples to give total 17/89 that account (19%).
| 2 |
Author(s):
Foluso Olamide Ojo, Hasiya Sule Buba, Abubakar Muhammad Bello, Wusa Makena, Sani Hyedima Garba, Luqman Adepoju Hassan, Fatsuma Buba Jajere.
Page No : 13-24
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Neuroprotective Effects of Curcuma Longa on Pentylenetetrazole-Induced Neurotoxicity on the Cerebrum and Hippocampus of Albino Wistar Rats.
Abstract
Epilepsy is a neurological disorder characterized by recurrent seizures, and current anti-epileptic drugs often have side effects. Curcuma longa, commonly known as turmeric, has been traditionally used for various medicinal purposes, including the treatment of neurological disorders. This study investigates the neuroprotective effects of Curcuma longa in pentylenetetrazol (PTZ)-induced epilepsy in albino rats. Group one received normal feed (control), Group two received PTZ to induce epilepsy intraperitoneally. Group three received PTZ with feed, Group four received a low dose of Curcuma longa with PTZ, and Group five received high dose of Curcuma longa with PTZ. The experiment lasted for 28 days, during which seizure severity and neurotoxicity were assessed. The results revealed that PTZ administration significantly increased seizure severity and frequency, as well as oxidative stress and neuroinflammatory markers. Treatment with Curcuma longa extract, particularly at the low dose and high dose, significantly reduced oxidative stress and neuro inflammation and improving neuroprotection. These findings suggest that Curcuma longa extract may have potential neuroprotective effects and anticonvulsant property making it a promising candidate for adjunctive therapy in epilepsy management.
| 3 |
Author(s):
Hassan Luqman Adepoju, Adamu Shettima Pogu, Lawal Rasheed Tunde, Foluso Olamide Ojo, Abdul Dimeji Ishola, Hasiya Sule Buba.
Page No : 25-35
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Ameliorative Effects of Tannin Fractionate of Cyperus Esculentus Tuber on Lead-Induced Hepatotoxicity in Wistar Rats.
Abstract
Aims: Hepatoprotective activity of the tannin fraction of Cyperus esculentus was studied against lead-induced hepatotoxicity in Wistar rats.
Materials and Methods: Twenty adult male Wistar rats were divided into four (4) groups, (A-D) (n=5). Group A was administered normal saline only. Groups B, C, and D were fed 30mg/kg body weight of lead. Additionally, groups C and D were administered with 50mg/kg body weight and 100mg/kg body weight of tannin fraction of Cyperus esculentus respectively orally for 28 days. The following day after the last administration, the animals were sacrificed under 50 mg/kg body weight of thiopental anesthesia, and blood samples were obtained through the intra-cardiac puncture to assay the levels of liver enzymes [Aspartate transaminase (AST) and Alanine transaminase (ALT)] and oxidative stress markers [malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT)]. The liver of the rats was harvested, weighed, and fixed in 10% formol saline and sectioned for histological studies using hematoxylin and eosin.
Results: Results showed that treatment with lead was associated with decreased levels of SOD, CAT, GSH, and increased MDA activities. Also observed is a significant increase in liver enzymes (AST and ALT) in the Lead-treated group. The histological result revealed alterations of hepatic structure including hepatocytic vacuolations and sinusoidal congestion following lead treatment. While treatment with tannin fraction of Cyperus esculentus prevented and reversed lead-induced hepatic injury.
