Evaluation of the Hypoglycemic Effect of Bali-bali Plant (Euphorbia tirucalli Linn. Family: Euphorbiaceae) Streptozocin-Induced Diabetes Mellitus in Sprague Dawley Rats

Abstract:

To extract bali-bali plant using ethanol extract, to evaluate short-term general toxicity of the extracts, to determine the hypoglycemic effects of bali-bali extract and to evaluate the effects of ethanolic extract of Euphorbia tirucalli on fasting blood glucose. A total of 84 Sprague-dawley rats of both sexes were employed and were divided into 7 groups. Group 1 served as the normal control, group 2 served as the negative control (NSS), group 3 served as a positive control (Metformin 200mg/kg), group 4 served as diabetic control (STZ only), groups 5-7 served as the treatment groups which were treated with the Bali-bali extract orally for two weeks. The FBG level of each group was measured using one touch glucometer on days 0, 7, and 15. Result in the toxicity analysis, the plant extract was shown to have little to no significant toxicity shown in the various dosages of the extract administered Kto the rats. Bali-bali was shown to have a significant effect on blood sugar causing hypoglycaemia with significant decrease in blood glucose level at the various dosages with the 75mg/kg dose seen to be more effective. The Fasting Blood Glucose evaluation revealed no statistically significant difference in the various dosages of bali-bali extract 50mg (p = 0.550), 75mg (p = 0.181) and 100 mg (p = 0.679) administered to the rats.