---

Author(s): Silas David Emmanuel, I.M. Bugaje, U. Suleman, S. M. Mohammmad, B. Aliyu.

Volume/Issue: Volume 4 , Issue 4 (2021)

Abstract:

Purpose: The unprecedented global pandemic from Covid-19 infection has generated significant chaos to humanity in both health wise and as well as economically. Thus, there have been no specific pharmacological and antiviral therapeutic option to date available for covid-19 management. For these reasons, there have been urgent needs to discover an effective medicine for preventive, and eradication methods due to the hash nature of death toll from this novel corona virus infection. Methods: Repurposing of selection, characterization of bacteria through genomic / traditional, phytochemical and fermentation methods base anti covid-19 drugs discovery. Thus, these approaches and techniques is essential to provides a better lead or otherwise. Results: Taking a bold step of faith to approach the techniques for Covid-19 methods, the results for microbiological screening of bacterial reveals that Bacillus sp (spore former, motile, rod (+) was pin-point to have the highest colony followed by Pseudomonas sp alongside with Klebsiellas sp(Capsule formers ,motile and rod (+)) and the least were found with both shigella sp (none motile, Rod (-ve) and Staphylococcus sp (cocci (+). Phytochemical screening of different plants both in qualitative and quantitative methods using Raphanu satinus, Neem (Azadirachata indica), Bagaruwa (Acacia nilotica), Moringa (Moringa oleifera) etc., respectively contain all the natural antioxidant, bioactive compounds, vitamins as well as an appreciable amount of micronutrient/ macronutrient for combatting covid-19 pandemic. Further investigation through fermentation processes were accentuated with time differences have reveal microbial crude proteins (%), pH and dry matter values have significant changes to all the specific species. Thus, there were significant increase in proteins, pH values decrease as well as dry matter decreases in this order% ProteinDM respectively. Originality: in view of this current investigation anti covid-19 leads translated through microbial screening, phytochemical as well as fermentation processes could overcome the current challenges of covid-19 pandemic therapy. Considering the immense potential of phytochemical, microbiological and fermentation processes, this article summarizes the present status of the research carried out on their anti-covid-19 activities with its limitation and futuristic direction to foster drug discovery.

Keywords:

Genomic/traditional screening, Phytochemical; Anticovid-19 pandemic; drugs discovery; fermentation

No. of Downloads: 0