Assessment of the Migration/Invasion Traits of Acquired Resistant BT 549 Gem100nM Breast Cancer Cell Lines.
Publication Date: 29/11/2024
Author(s): Tawari Erebi Patricia.
Volume/Issue: Volume 7, Issue 4 (2024)
Page No: 90-96
Journal: African Journal of Biology and Medical Research (AJBMR)
Abstract:
One of a cell's behavioral characteristics is migration. Cell migration is a major contributor to cancer-related mortality and plays a significant role in the spread of metastatic tumors. The purpose of this study was to evaluate the invasive characteristics and migration traits of acquired gemcitabine-resistant BT 549 Gem100nM breast cancer cell lines. According to data from the results obtained, the resistant cell lines Clones 1 and 4 exhibited higher migratory and invasive activities than the wild-type cell line BT549. This suggests that acquired resistance may cause cancer cells to become more lethal by increasing their migratory and invasive characteristics.
Keywords:
Migration, Invasion, Acquired Resistance, BT 549 breast cancer cells.
