The Protective and Currative Effect of Ficus Vogelii against Toxicity Induced by Lead-Acetate on Spleen in Adult Wistar Rats
Publication Date: 03/10/2018
Author(s): Uchewa O. Obinna, Okafor O. Samuel , Okoronkwo A. Christiana.
Volume/Issue: Volume 1 , Issue 1 (2018)
Abstract:
Objective: This study aimed at investigating the protective and currative effect of Ficus vogelii against toxicity induced by lead acetate on spleen in adult Wistar rats. Methodology: Thirty (30) Wistar rats were used for this research and randomly assigned into 6 groups of five rats. Group A (Control group) received normal saline and water ad libitum. B was given lead acetate in a dose of 2mg/kg body weight for 28 days. The currative groups C (low dose) and D (high dose) received lead acetate and aqueous extract. The protective groups E (low dose) and F (high dose) received aqueous extract and lead acetate. Group G were given only aqueous extract. The experiment lasted for 28 days after 7 days of acclimatization. Results: Figure 1C showed lymphoid follicle with little necrosis demonstrating the effects of the extract as currative herb. Figure 1D shows expansion of red pulp and macrophages with relative improvement when compared to positive control. Figure 3E shows lymphoid follicle with necrosis and affected trabeculae (T). Figure 3F showed diffused red pulp and necrotized macrophages (arrows) which are not as much as that found in the positive control group and may be attributed to the protective role of the extract. The extract only (Figure 4) group shows normal histoarchitecture with red pulp, white pulp, microphages, trabeculae and lymphoid follicle all intact without any injury. Conclusion: This experiment demonstrates that lead causes splenic alterations like diffusion of white pulp into red pulp and appearance of large macrophages due to inflammations and production of debris of dead cells. These alterations can either be ameliorated or protect against by Ficus vogelii extract.
